Victoria Costello

Psychology and Health Author

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More from The Chemistry of Love


According to evolutionary psychologists, the instinct to reproduce still wields a big influence over who you find hot, or not. It takes two lusty chemicals, dopamine and testosterone, just to free any two people from their instinctual fear of strangers. And then make them forget about their last romantic heartbreaks.

Once you're open and aroused, two hard-hitting natural stimulants (norenpinephrine, the “fight or flight” agent in our brains, and PEA, the chemical associated with “love at first sight”) are released to get you hooked and transport you from that bar stool to a bed. Without these hormones and neurotransmitters, happy hours and dating websites would be lonely places.

Some Timeless Mysteries, Solved

Let the fog lift.

Why "I Have a Headache" is not the end of the conversation

When thinking about the chemistry of female arousal, it's important to distinguish between a woman's sexual desire and her response to arousal. The former helps stoke the latter, but it's not essential. This is something that hasn't always been understood, resulting in far too many standoffs between horny men and ostensibly disinterested women across the land.

Here's a surprise. Sexual desire by itself is an uncommon reason for women to initiate sex or for a woman to agree to sexual activity. Women have sex for many other reasons before desire: to make an emotional connection, to please a partner, even to avoid a spat. Meanwhile men, at least until they reach their forties, are walking around with a seemingly inexhaustible supply of sexual desire.

Men’s Sexuality is Simple and Constant. True or False?

There is a mistaken impression out there that male sexuality is a one-act play, the course of a man's arousal and sexual satisfaction therefore a no-brainer, the changes over his life cycle minimal. Partly, this misunderstanding has to do with the fact male genitalia are external, and thus more easily understood (and aroused).

But as any man or any woman in a long term relationship is well aware, there are moods and seeming mysteries attached to men's sexuality too. There are times when a man in his thirties and forties cannot achieve an erection and he doesn't have a clue why he can't. There are times when stress feeds his sexual desire and still others when disappointment over some perceived failure in his life kills all thoughts of sex. Could it be that a man's emotions have more to do with his sexual performance than he thought? This would put a dent in the "man as sex machine" theory, and that might not be a bad thing.

One major difference between men's and women's sexual response has to do with a woman's greater susceptibility to fears and anxieties that can distract her from sexual arousal.

Why Women Lose Interest Midstream

Unlike a man, who once he gets half way there is a goner, a woman can lose interest in sex at any moment up to and including orgasm. For a woman to stay turned on, the fear-worry circuit in her brain must be turned off.
How does fear or worry cause a woman to turn off sexually? Negative feelings such as fear and anxiety are modulated in the amygdale. When activated the amygdale sends its chemical messengers to the frontal cortex. If emotional distractions flare up for a woman during any point in the arousal stage, the announcement goes out loud and clear from her brain to the rest of her body: "forget sex."

News to Use

A man's high testosterone level in the morning makes him most virile upon waking. This explains why men often wake up with an erection. Comparatively, he's got less desire at noon or dusk, especially as he ages.
Studies have shown that men with the highest testosterone levels and the most handsome men are more likely to cheat on their partners and be divorced. Could this be evidence of too much of a good thing? Researchers say the evidence points to exactly that conclusion.

Sexual desire and testosterone levels are linked in an unending feedback loop in men. Testosterone is increased through his regular sexual activity, and high testosterone leads him to want and have more sex. In addition to increasing a man's sex drive, a higher level of testosterone is beneficial to a healthy heart and brain. It produces a buoyant effect on his mood and energy level.


That's it for now. Suffice to say, from the forward march of evolution to what you ate for dinner, everything you do, think, feel, and consume through your five senses, as well as what you remember personally--all of it comes into play in the chemistry of love. Those are a lot of forces at work. The good news is that each part of the whole, meaning your brain, your feelings and every cell in your body, is elastic and fluid. You can always change things for the better. It's the wonder of chemistry.


A Lethal Inheritance, A Mother Uncovers the Science Behind Three Generations of Mental Illness
From page one...

Alex by the Dumpster
Where it begins


“How would you describe Alex’s recent behavior?”

The psychiatrist asked me this question with her eyes still peeled to my son’s admission file. While searching for the right words to describe the terrifying changes I’d seen come over Alex during the previous 12 months, I flashed on the afternoon I’d found him hiding among the trash bins behind Fairfax High School. The image made my stomach retch.
“He’s been withdrawn and he has a lot of trouble sleeping,” I said flatly, as if by muting that one awful memory, Alex might not be as crazy as I feared.

Later I found an entry in Alex’s journal, dated October 15, 1997, giving his perspective on the same afternoon.

I sat down behind a dumpster, declared it my kingdom and began drawing soldiers. I drew an angel with eyes and tits. I drew knights to fight my holy war. I began to forget that I was back there cause I was scared of the world.

Alex’s art teacher made a heroic attempt earlier that day to keep him in her class, saying he could draw or paint whatever he wished. At 3:00 when I entered the rear parking lot where I usually pick him up, he was crouched between the dumpster and a cement wall. After the third time I called his name, he stood up and walked slowly to the car. He said the pressure had gotten to him.

For more go to THE NEW STUFF, right column.

The New Stuff

A Lethal Inheritance, A Mother Uncovers the Science Behind Three Generations of Mental Illness
Every family has secrets; only some secrets are lethal. In A Lethal Inheritance, I recount how the mental unraveling of my 17 year old son Alex compels my look back into our family history for clues to his condition, eventually tying Alex’s descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather’s suicide on a New York City railroad track in 1913. I use my journalism skills to search out and assemble the startling new neuroscience that explains how clusters of mental illness traverse families such as ours; findings that the clinicians I meet are using to identify and reverse early signs of inherited depression in patients as young as five and psychosis in nine to 12 year olds.